Archive for 2010

Benchmarks articles from the selected year appear below. To view articles from previous years, use the links to the left, and select the year you wish to see.

Lung Cancer Screening Using Helical CT vs. Chest X-ray Reduces Deaths among Current and Former Heavy Smokers

Computed tomography (CT) scan of the abdomen; drawing shows the patient on a table that slides through the CT machine, which takes x-ray pictures of the inside of the body.

a study sponsored by the National Cancer Institute (NCI) has determined that low-dose helical computed tomography (CT) scans can reduce lung cancer mortality for current and former heavy smokers. In the nation-wide study, which included over 53,000 participants, researchers found 20 percent fewer lung cancer deaths among those who were screened with low-dose helical CT (also known as spiral CT) compared with those who were screened with chest X-rays. In addition, deaths from all-causes (including lung cancer) were seven percent lower in those who received the low-dose helical CT scans.

HPV Infection and Transformation [Animation]

HPV can infect normal epithelial cells. The human papilloma virus is housed in a protective shell made of a protein called L1. As the virus enters a cell, the L1 protein coat degrades, leading to the release of the virus’ genetic material in a cell’s nucleus. In the nucleus, the DNA from the virus is transcribed by messenger RNA, which carries viral DNA snippets to the cellular DNA, where it is integrated and eventually translated into proteins called E6 and E7, which can lead to cancer.

Studies Uncover Associations between Human Papillomavirus and Oral Cancer

Release of HPV genetic material in a cell’s nucleus.

NCI-supported research is contributing to the understanding of how the human papillomavirus (HPV) causes oral cancer. These research efforts are identifying factors and behaviors that may put some people at high risk for the disease. While oral cancer caused by tobacco use has declined over the past 30 years, oral cancers associated with HPV have [...]