Articles Posted in ‘Cervical cancer’

Changes in cancer rates when health behaviors shift [includes video]

Chart shows lung cancer incidence broken down by race

With the release of 2009 data from NCI’s SEER program on April 16, 2012, experts point to a continuing statistically significant decline in lung cancer mortality for women. This turning point was particularly important, as lung cancer is the No. 1 cancer killer for both men and women. Lung cancer cases make up nearly a quarter of all cancers deaths in the U.S. A continuation of the trends showing a drop in lung cancer mortality for both sexes would indeed be good news for the health of the nation.

HPV Infection and Transformation [Animation]

HPV can infect normal epithelial cells. The human papilloma virus is housed in a protective shell made of a protein called L1. As the virus enters a cell, the L1 protein coat degrades, leading to the release of the virus’ genetic material in a cell’s nucleus. In the nucleus, the DNA from the virus is transcribed by messenger RNA, which carries viral DNA snippets to the cellular DNA, where it is integrated and eventually translated into proteins called E6 and E7, which can lead to cancer.

NCI Pursues Vaccines to Prevent and Treat Cancer

How immune cells are activated to attack foreign invaders

Vaccines are commonly used to prevent diseases such as measles, mumps, and polio. In addition to preventing sickness, cancer researchers want to capitalize on the ability of vaccines to stimulate the body’s immune system to mount an assault on existing cancer cells.

In this issue, BenchMarks examines prevention and treatment cancer vaccines. A fact sheet provides the latest information on how cancer vaccines are being made, which are furthest along in testing, and what cancers are being targeted. To get a better picture of how cancer vaccines work, click on the animation, which shows how immune cells are activated to attack foreign invaders. The main BenchMarks article is an interview with Douglas Lowy, M.D., from the National Cancer Institute (NCI) who has developed the technology underlying the prevention vaccine for human papillomavirus (HPV), which causes cervical cancer. Lowy, along with other NCI vaccine researchers, also spoke at a Science Writers Seminar on March 21, 2003 (PowerPoint presentations are available, and a video archive of the seminar can be found at http://videocast.nih.gov). BenchMarks has provided a soundbite from Lowy’s BenchMarks interview, which can be found at the audio clips button. And stills from the animation are also available.