Articles Tagged ‘screening’

Fagerstrom discusses landmark lung cancer screening trial

Richard Fagerstrom, Ph.D., an NCI mathematical statistician from the Division of Cancer Prevention, was the co-chief statistician for the National Lung Screening Trial, a nearly decade-long study that showed a 20 percent reduction in lung mortality among heavy smokers screening with low-dose CT, compared to those screened with X-ray. In this interview from June 2011, Fagerstrom discusses the trial, from concept design to primary results.

Sequencing techniques uncover mutations in genes that can increase cancer risk

Device on benchtop in lab, featuring open lid for placement of microarray chip and to the right, a read-out screen.

Sequencing the human genome was just the beginning—now that the findings from that landmark effort are widely available, scientists are working to put that data to work to understand the genetic causes of many diseases, including cancer, by using the latest sequencing techniques.

Overview of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

In 1993, the National Cancer Institute launched one of the largest cancer screening trials ever planned in the United States, in an effort to answer the question of screening efficacy in four cancers: prostate, lung, colorectal, and ovarian. Ten centers across the country ultimately accrued more than 150,000 men and women for this study. Nineteen years after it began, PLCO has now released the trial’s final major outcome finding, for colorectal cancer.