Scientific discoveries typically begin at the bench, with basic research through the study of diseases at a molecular or cellular level, then progress to the clinical level, or the patient’s bedside. Scientists are increasingly aware that this bench-to-bedside approach to translational research is actually a two-way street. Basic scientists provide clinicians with new tools for use in patients and for assessment of their impact, while clinical researchers make novel observations about the nature and progression of disease and gather biospecimens that are necessary to fuel the next generation of basic investigations.